Lam Research Group

Welcome

Welcome to our electrifying world of innovative chemistry! Our research is a deep dive into the potential of organic electrosynthesis, where we are  pioneering new strategies for synthesising highly reactive intermediates and revolutionising the way we understand and use electrochemistry. We're not just exploring the science, we're reshaping it, using cutting-edge approaches such as flow electrochemistry and pushing the boundaries of medicinal electrosynthesis. Join us on this journey of discovery and innovation as we unlock new potential and redefine the boundaries of chemistry.

Recent Publications

eCarbonyls: an electrochemical thioether mediated oxidation of alcohols to aldehydes and ketones

We report eCarbonyls, a scalable, metal-free electrochemical oxidation of alcohols that mimics key features of the classical Swern reaction while avoiding its reliance on cryogenic conditions and hazardous reagents.

In this work, we disclose a novel electrochemical approach that enables the synthesis of sterically hindered ethers from economically relevant and readily accessible alcohols without the need for sacrificial oxidants. Our protocol exploits mild conditions to generate reactive carbocations, which are subsequently captured by alcohol nucleophiles to yield the desired ethers. This method is cost-effective, practical, and broad in scope, providing a valuable addition to chemists’ synthetic toolkit for ether synthesis.

eEtherification: An Electrochemical Strategy toward the Synthesis of Sterically Hindered Dialkyl Ethers from Activated Alcohols

eFluorination for the Rapid Synthesis of Fluorothioformates from Oxalic Acid Monothioesters

An efficient and practical electrochemical method for synthesizing fluorothioformate derivatives, an underexplored functional group, is reported. The strategy is based on the anodic decarboxylation of oxalic acid monothioesters, which rapidly generates highly reactive alkyl (oxomethylidene)sulfonium intermediates.

eSpiro: A scalable and sustainable electrosynthetic route to spiroketals via anodic oxidation of malonic acids

Here, we present eSpiro, a novel electrosynthetic method for the efficient and sustainable synthesis of spiroketals via anodic oxidation of malonic acids. This approach offers a metal- and mercury-free alternative to conventional acid-catalysed or transition metal-mediated cyclisations.